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Welcome to the North West Regional Paediatric Immunodeficiency Unit. We are based at the Royal Manchester Children's Hospital, the largest children's hospital in the UK.  Because of the multi-ethnic make-up of the population, the North West region has one of the highest rates of children with primary immune disorders in the Western World - 1 in 3,600 children compared with estimated rates of 1 in 10,000 for Europe and the US. Our teams of paediatric specialists and nurses help to look after over 400 children with defined genetic immune disorders, encompassing all innate and acquired primary immunodeficiency diseases.

Children are treated with the very latest therapies, including both intravenous and subcutaneous immunoglobulin replacement, biologic agents and stem cell transplantation. At present children with severe combined immune deficiency (SCID) are referred to supra-regional paediatric BMTU in Newcastle upon Tyne, with which we have close links. Transplants for non SCID immune deficiency are performed locally.

The unit has close links with colleagues from all other paediatric disciplines within RMCH including PICU, respiratory, ENT, gastroenterology, rheumatology, haematology/oncology, neurology, nephrology and laboratory immunology.


Department of Paediatric Allergy and Immunology
Royal Manchester Children's Hospital
Oxford Road
M13 9WP

Contact Details

Telephone: 0161 701 0678
Fax: 0161 701 5421


Dr Peter Arkwright
Dr Stephen Hughes
Professor Robert Wynn (Director of Paediatric Bone Marrow Transplantation Unit

Specialist Nurses

Sister Barbara Boardman
Sister Judith Stafford
Sister Samantha Farrer

Administrative Staff

Mrs Marjorie Whitehead marjorie.whitehead@cmft.nhs.uk

Service Description


Specialist paediatric immunology out-patient clinics for children with severe or unusual infectious diseases, or those with suspected immunodeficiencies are held weekly each Tuesday morning. Joint clinics with respiratory, gastroenterology, rheumatology and haematology/BMT colleagues are held at regular intervals during the year for more complex cases. Transitional clinics with Clinical Immunologists from adult services are held as required. Dr Arkwright also conducts specialist immunodeficiency clinics at Royal Liverpool Children's Hospital at bimonthly intervals. Dr Hughes conducts specialist immunodeficiency clinics at the Royal Preston Hospital every month.

Day cases

Day patients and children requiring assessment and treatment lasting less than 72 hours are seen in the Elective Treatment Centre (ETC).


In-patients are either managed in the Tertiary Medicine Ward or in HDU/PICU if indicated. Patients undergoing stem cell transplantation are looked after in our nationally accredited regional paediatric bone marrow transplantation unit.

Home Care

Most patients requiring immunoglobulin replacement therapy are on treatment subcutaneously delivered by parents at home. Sister Boardman runs the home care programme, training and monitoring these patients. She also conducts home visits as required to resolve any technical difficulties that may arise.


The Department has a very active research profile, particularly with Dr Peter Arkwright jointly employed by the University of Manchester.  The Department maintains an internal database of all patients with primary immunodeficiency diseases (PID) and also contributes to the European Society of Immunodeficiencies in which Manchester has the third largest group of PID patients in the United Kingdom. The unit collaborates with other research groups locally, nationally and internationally, particularly with the Paediatric Immunology Unit at Hôpital Necker, Paris.

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