Research and Innovation

Research in the Children's Division is underpinned by comprehensive medical and surgical services that provide care to one million children and young people across the North-West.

There are very close links with other general paediatric services with an extensive network of district clinics, providing direct access to a large ethnically diverse population base with a wide range of pathology.

Dr Nick Webb, Deputy Director of GMLC CRN with a patient

The Royal Manchester Children's Hospital is also host to the Greater Manchester, Lancashire and South Cumbria Medicines for Children Local Research Network (MCRN) and the Paediatrics Speciality Group (PSG) for non medicines research, and therefore a large proportion of our research has their support.

The Division also hosts its own Children's Clinical Research Facility on site, and has successfully run a number of complex in-patient clinical trials in its first two years.  This facility is run through the quality assured procedures of the Wellcome Trust Clinical Research Facility (WTCRF) and with the additional support from the MCRN.

The Children's Division supports a wide range of research across 25 paediatric sub-specialties and contributes to the Genetics and Human Development theme, which is the main focus of the NIHR Manchester Biomedical Research Centre (BRC).

We excel at an international level in five areas:

  • Childhood Cancer
  • Child & Adolescent Mental Health
  • Growth Disorders and Endocrinology
  • Inherited Metabolic Disease (IMD)
  • Nephrology

with research supported by the National Institute for Health Research (NIHR), the Medical Research Council, major research charities such as Cancer Research UK and The Wellcome Trust, and Pharmaceutical companies.

We also have newly emerging research themes:

  • Immunology and Vaccines
  • Respiratory Disease

It is not only research into medicine that takes place at the Royal Manchester Children's Hospital, in fact a large proportion of research which currently takes place here involves a wide range of topics such as gathering information on young patients with rare disorders to help better understand their diseases and help develop treatment in the future.

A selection of current projects funded by NIHR and other major funders can be found below.

 

Projects Investigators
Does an interactive child-centred workshop reduce treatment-related distress and improve quality of life in children with leukaemia? Dr Guy Makin
Telephone consultation as a substitute for routine out-patient face-to-face consultation for children and adolescents with inflammatory bowel disease: randomised controlled trial and economic evaluation. Dr Tony Akobeng
The effects of parenting intervention on child behaviour, parental confidence and asthma management in young children Dr Clare Murray
The COMMEND YOU Study: Promoting COMMunication in ENDocrinology for YOUng people
Professor Peter Callery, Professor Peter Clayton, Helena Gleeson, Julian Davis
The OPIS (On-line Parent Information and Support) project: Empowering parents to manage home-based care-giving for chronic kidney disease stages 3-5 Veronica Swallow/Dr Nick Webb
PREDNOS - Long-term tapering versus standard prednisolone (steroid) therapy for the treatment of the initial episode of childhood nephrotic syndrome: national multicentre randomised double blind controlled trial Dr Nick Webb
TOPS - Timing of primary surgery for cleft palate Professor Bill Shaw
SHIFT Trial: Self harm intervention, family therapy: a randomised controlled trial of family therapy vs. treatment as usual for young people seen after second or subsequent episodes of self-harm. Professor Jonathan Green
IMPACT: Randomised Controlled Trial of Brief Psychodynamic Psychotherapy (BPP), Cognitive Behaviour Therapy (CBT) and Treatment as Usual (TAU) in adolescents with moderate to severe depression attending routine child and adolescent mental health clinics. Professor Jonathan Hill
Lysosomal Storage Disorders - Long term cohort study of people with Lysosomal Storage Disorders, the effectiveness and cost effectiveness of enzyme replacement therapy. Dr Ed Wraith

 

For further information about research in the Children's Hospital, please see our contacts page.