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Aldosterone

Paediatrics

Measurements are used in the diagnosis and treatment of primary hyperaldosteronism, hypertension, oedematous states and other conditions of electrolyte imbalance.

General information

Collection container: EDTA plasma (3.4 mL Sarstedt pink top).

Type and volume of sample: 1.0 mL whole blood is required, as a minimum volume. If renin is also requested then two tubes are required.

Specimen transport/special precautions: The tube should be thoroughly mixed before transport to the lab. Separate and freeze plasma immediately. External labs: send frozen plasma on dry ice.

Laboratory information

Method principle: Aldosterone concentration is analysed on an automated instrument using a chemiluminescent immunoassay.

Biological reference ranges:

Age Aldosterone Concentration (pmol/L)
<1 month 129-4856
1-12 months 139-2498
1-2 years 194-1499
2-10 years 83-971
10-18 years 56-611

 

Turnaround time: 1 month

Clinical information

Aldosterone secretion is stimulated primarily via the renin-angiotensin-aldosterone system (RAAS). The production of renin is stimulated when there is a reduction in the renal perfusion pressure, reduction in plasma volume and plasma sodium depletion. Renin cleaves angiotensinogen into angiotensin I which ultimately leads to the production of angiotensin II via the angiotensin converting enzyme. Angiotensin II acts on the vascular system causing vasoconstriction as well as stimulating the adrenal cortex to secrete aldosterone.

Aldosterone acts on the mineralocorticoid receptors within the principal cells of the distal tubule to increase sodium and chloride reabsorption and potassium and hydrogen secretion.

Aldosterone measurements are used in the diagnosis and treatment of primary hyperaldosteronism, hypertension, oedematous states and other conditions of electrolyte imbalance.

Factors known to significantly affect the results:

  • Grossly haemolysed samples are unsuitable for analysis.
  • Grossly lipaemic samples are unsuitable for analysis.

 

(Last reviewed 29th February 2016)