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Guidelines for heparin dosage - SC

Here are the Haematology department's guidelines for SC heparin dosage for heparinisation for thrombotic conditions.

For S C Heparin 250 iu/kg b.d. [200 for females > 60yrs]. Take specimen four to six hours post injection.


APTT ratio Dose adjustment Repeat APTT
<1.5 +2,500 units b.d. Next Morning
1.5-2.0 +1.250 units b.d. Next Morning
2.0-3.0 No change Next Morning
3.0-3.5 -1,250 units b.d. Next Morning
3.0-4.0 -2,500 units b.d. Next Morning
>4.0 -5,000 units b.d. Next Morning