The Leukaemia Laboratory has a number of major themes contained
within the umbrella of diagnosis and treatment of haematological
One of the major problems of leukaemia, for example, is that
although patients may enter remission after chemotherapy, a large
proportion subsequently relapse with their disease.
One novel approach is the use of immunotherapy to stimulate the
patient's own immune system to recognise and attack their
Disease could be brought under control using chemotherapy then
immunotherapy could stimulate the immune system to attack any
residual disease thus prolonging the remission period and possibly
eradicating the leukaemic cells totally.
We are currently investigating the production of dendritic cells
(central to the generation of a specific immune response) and ways
to stimulate T cells to recognise and destroy leukaemic cells. We
hope to carry this forward to phase one clinical trial.
Another area of interest includes in vitro work on specific
antibodies conjugated to a toxin which can bind to leukaemic cells,
be internalised and prevent the cell from dividing and the
effectiveness of combining the antibody with low dose
We regularly accommodate and supervise various students ranging
from four week medical student placements to year-long Salford
University work experience, through to longer term MSc, MD and PhD