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Normal Karyotype AML testing

Note that FLT3 testing is currently performed by LabPMM. As many patients do not have a specific translocation to facilitate MRD monitoring, we routinely monitor for NPM1 and FLT3-ITDs on the diagnostic pre-treatment sample.

This is usually done on PB alone for FLT3-ITDs and both PB and BM for NPM1. In addition, the FLT3 D835 TKD variant is screened for.

Separate samples are required for FLT3-ITD and NPM1 screening because the tests are carried out on DNA and RNA respectively.

 

(Last reviewed 12th February 2018)