Heritable bleeding disorders
The MDC has close links with the Comprehensive Care Haemophilia
Centres at Manchester Royal Infirmary (MRI) and the Royal
Manchester Children's Hospital (RMCH). Genetic diagnosis in
heritable bleeding disorders, including clinical scientific
interpretation of individual cases, is provided to these
haemophilia centres and also, as required, to other centres
nationally and internationally.
Comprehensive genetic diagnosis is presently available for
haemophilia A, haemophilia B, von Willebrand disease (VWD), FXI
deficiency, and FVII deficiency.
It is the referring clinician's responsibility to obtain and
record informed consent prior to genetic diagnosis in all heritable
bleeding disorders. In this regard, it is also the referring
clinician's responsibility to inform the laboratory of any
restrictions on consent (for example to store genetic information
on confidential databases, or to apply an individual's genetic
information in the diagnosis of other family members). A standard
consent form and patient information leaflet is in use within the
CMFT Comprehensive Care Haemophilia Centres.