The MDC provides a diagnostic referral service for genetic risk
factors for venous thromboembolism (VTE), specifically for the
identification of the FV Leiden mutation and the prothrombin gene
Phenotypic assays to measure antithrombin, protein C and protein
S, rare deficiencies of which are associated with increased risk
for VTE, and also lupus anticoagulant screening, are available from
the Blood Coagulation Laboratory at CMFT.
Note: There is convincing evidence that homozygosity for the
methylenetetrahydrofolate reductase (MTHFR) genetic variant C677T
is not a risk factor for VTE. There is no rationale for MTHFR C677T
genotyping for clinical diagnostic purposes in VTE, hence this is
not offered by the MDC.