Thrombophilia testing in children is only available after
discussion with a clinical haematologist.
The annual incidence of VTE in children is about 1/100,000 in
the general population. There is a bimodal distribution with peaks
in the neonatal period and in adolescence.
More than 90% of paediatric thrombotic events are related to
underlying medical or surgical risk factors, central venous lines
D-dimers should not be used to diagnose or exclude VTE in
Testing for heritable thrombophilia in unselected children
presenting with a first VTE is not indicated. Testing has uncertain
predictive value for recurrence.
Neonates and children with purpura fulminans should be tested
urgently for PC and PS deficiency.
Children with early onset spontaneous thrombosis should be
investigated for AT deficiency
Children presenting with unprovoked VTE should be tested for