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Thrombophilia testing in children is only available after discussion with a clinical haematologist.

The annual incidence of VTE in children is about 1/100,000 in the general population. There is a bimodal distribution with peaks in the neonatal period and in adolescence.

More than 90% of paediatric thrombotic events are related to underlying medical or surgical risk factors, central venous lines in particular.

D-dimers should not be used to diagnose or exclude VTE in children.

Testing for heritable thrombophilia in unselected children presenting with a first VTE is not indicated. Testing has uncertain predictive value for recurrence.

Neonates and children with purpura fulminans should be tested urgently for PC and PS deficiency.

Children with early onset spontaneous thrombosis should be investigated for AT deficiency

Children presenting with unprovoked VTE should be tested for anti-phospholipid antibodies.


(Last reviewed 12th February 2018)