Recurrent pregnancy loss
There is an association of FV Leiden and PGV with recurrent
early and late pregnancy loss. However these are weak contributors
to risk rather than the sole cause of pregnancy loss.
Testing for heritable thrombophilia is not recommended. Testing
for the presence of antiphospholipid antibodies should be
Recent large clinical trials of antithrombotic therapy have
indicated no benefit of low molecular weight heparin in preventing
recurrent early pregnancy loss in the absence of thrombophilia.
Further research is required to determine if LMWH may improve live
birth rates in women with recurrent pregnancy loss in the presence