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Recurrent pregnancy loss

There is an association of FV Leiden and PGV with recurrent early and late pregnancy loss. However these are weak contributors to risk rather than the sole cause of pregnancy loss.

Testing for heritable thrombophilia is not recommended. Testing for the presence of antiphospholipid antibodies should be undertaken.

Recent large clinical trials of antithrombotic therapy have indicated no benefit of low molecular weight heparin in preventing recurrent early pregnancy loss in the absence of thrombophilia. Further research is required to determine if LMWH may improve live birth rates in women with recurrent pregnancy loss in the presence of thrombophilia.