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Allergen Specific IgE

General information

Measurement of allergen specific IgE is of value where skin testing is difficult for any reason. Over 100 specific allergens are routinely available. Any requests for allergens that are unusual should be discussed with a clinician.

Specimen transport: At room temperature

Repeat frequency: >1 year unless marked changes in allergic condition

Special precautions: None

Laboratory information

Normal reference range: <0.35 kAU/L

Volume and sample type: 7ml clotted blood (14 ml required for multiple allergens)

Method: ImmunoCAP 1000

Turnaround time (calendar days from sample receipt to authorised result): Median - 3

Clinical information

Indications for the test: Allergic conditions when allergen is suspected and mentioned on request

Factors affecting the test: Total IgE >3000ku/L increases the incidence of false positive (low level) specific IgE. IgE <30 ku/L associated with false negative specific IgE. Similarly, very low IgE levels (<2.0 kU/L) may result in a false negative result and possibly indicate an underlying immunodeficiency; measurement of immunoglobulins is recommended.


(Last updated August 22nd 2018)