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Aspergillus fumigatus precipitins

General information

Precipitin testing: These tests detect the presence of IgG antibodies to Aspergillus fumigatus, Aspergillus precipitins - see also: Farmer's lung and Avian Precipitins

Specimen transport: At room temperature

Repeat frequency: On appearance of new symptoms

Special precautions: None

Laboratory information

Normal reference range: 0-40 mg/L

Volume and sample type: 7ml clotted blood

Method: FEIA (Fluoroenzyme immunoassay)

Turnaround time (calendar days from sample receipt to authorised result): Median - 1, 95th percentile - 5

Clinical information

Indications for the test: Allergic bronchopulmonary aspergillosis - IgG antibodies are a useful aid to diagnosis in the following settings:

  • Bronchopulmonary aspergillosis; usually presents as deteriorating or brittle asthma. IgE antibodies should also be checked.
  • Aspergilloma; these may form in cavities or bronchiectatic lung. For example, this test is used to check for aspergilloma in patients with cystic fibrosis.
  • Hypersensitivity pneumonitis 24 hours after inhalation of spores.

Factors affecting the test: Aspergillus antibodies are not a recommended test for the investigation of the majority of cases of invasive aspergillosis in immunocompromised hosts.

Interpreting results:

IgG antibodies are infrequent in healthy individuals.

In hypersensitivity pneumonitis, IgG antibodies are usually present alone. IgG antibodies, without IgE antibodies can also be seen in some cases of sub acute invasive aspergillus.

In bronchopulmonary aspergillosis and aspergilloma a mixture of IgE and IgG antibodies are usually present. Bronchopulmonary aspergillosis can be caused by species other than A. fumigatus: if there is a high index of suspicion, we can send a sample to the reference laboratory to look for antibodies to other Aspergillus species. In allergic rhinitis and asthma, where aspergillus is a relevant allergen, IgE antibodies dominate.


Clinical workstation reference: ASPERGILLUS


(Last updated October 7th 2014)