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Bence Jones Protein (Urinary light chains) Urine immunofixation

General information

Specimen transport: Specimen should ideally be sent fresh

Repeat frequency: Post treatment monitoring and MRD as required

Special precautions: None

Laboratory information

Normal reference range: Absent

Volume and sample type: 20ml urine

Method: Immunofixation

Turnaround time (calendar days from sample receipt to authorised result): Median - 5

Clinical information

Indications for the test: Suspected myeloma, Waldenström's macroglobulinaemia, rarely lymphoma.

Factors affecting the test: 24 hour urine is more sensitive. Polyclonal free light chains may be found with renal tubular damage, old age, chronic inflammatory conditions (like RA).

Monoclonal light chains may also be found associated with prostatic problems in older men.


ICE reference: Bence Jones Protein


(Last updated August 22nd 2018)