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Beta 2 Glycoprotein (IgG and IgM)

General information

Anti-phospholipid syndrome (APS) is an acquired autoimmune condition. The clinical features are venous, arterial and microvascular thrombosis and/or pregnancy complications. Testing for β2GP1 antibodies can be helpful for APS diagnosis, particularly when anti-cardiolipin antibodies and lupus anticoagulant are negative and APS is strongly suspected.

Specimen transport: At room temperature

Repeat frequency: The British Society for Standards Clinical Haematology guidelines requires anti-cardiolipin, lupus anticoagulant or Anti-β2-glycoprotein I to be present on two or more occasions at least 12 weeks apart to diagnose anti-phospholipid syndrome antibody.

Special precautions: None

Laboratory information

Reference range Normal
IgG β2GP1 0-19.9 kU/l
IgM β2GP1 0-19.9 kU/l

Volume and sample type: 7ml clotted blood

Method: Multiplex flow immunoassay

Turnaround time (calendar days from sample receipt to authorised result): Median: 1

EQA scheme: UK NEQAS Scheme for Phospholipid antibodies.

Clinical information

Indications for the test: This test should be used when investigating a patient for anti-phospholipid syndrome. The clinical features of anti-phospholipid syndrome are detailed above.

Factors affecting the test: β2GP1 antibodies should not be relied upon as a diagnostic tool but must be used in conjunction with evaluation of clinical, pathological and imaging features.


ICE reference: Beta 2 Glycoprotein

(Last updated August 22nd 2018)