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Cardiolipin (IgG and IgM) antibodies

General information

Found in the anti-phospholipid syndrome, which may be primary or occur as a secondary complication of SLE. Elevated levels are significantly associated with the presence of both venous and arterial thrombosis, thrombocytopaenia, and recurrent fetal loss.

Specimen transport: At room temperature

Repeat frequency: The British Society for Standards Clinical Haematology guidelines requires anti-cardiolipin, lupus anticoagulant or  Anti-β2-glycoprotein I  to be present on two or more occasions at least 12 weeks apart to diagnose anti-phospholipid syndrome antibody.

Special precautions: None

Laboratory information

Normal reference range: IgG 0-5.6 GPLU, IgM 0-10 MPLU

Volume and sample type: 7ml clotted blood

Method: FEIA (Fluoroenzyme Immunoassay)

Turnaround time (calendar days from sample receipt to authorised result): Median - 1, 95th percentile - 4

EQA scheme: UK NEQAS Scheme for Phospholipid antibodies

Clinical information

Indications for the test: Thrombosis, miscarriage

Factors affecting the test: False positives in infections

Clinical workstation reference: CARDIOLIPIN

References:

(Last updated July 11th 2016)