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General information

Specimen transport: Sample in Thermos at 37°C. Contact the laboratory to arrange collection of the Thermos flask.

Repeat frequency: At significant change of clinical symptoms.

Special precautions: The sample must be taken into a prewarmed syringe and then pre-warmed tubes. It must be transported at 37°C in a Thermos flask. Always contact the laboratory before bleeding the patient.

Laboratory information

Normal reference range: Not normally detected

Volume and sample type: 7ml clotted blood maintained at 37°C

Method: Immunofixation

Turnaround time (calendar days from sample receipt to authorised result): Median - 4

Clinical information

Indications for the test:

  • Lymphoproliferative disease (Monoclonal)
  • Connective tissue disease: SLE, Sjogren's, Raynaud's and cutaneous vasculitis.
  • There is almost always a low C4 in cryoglobulinaemia

Factors affecting the test: Any minor variations in temperature (1°C)


ICE reference: Cryoglobulins


(Last updated August 22nd 2018)