We use cookies to help us improve the website and your experience using it. You may delete and block all cookies from this site at any time. However, please note this may result in parts of the site no longer working correctly. If you continue without changing your settings we will assume you are happy to receive all cookies on this site.


Glomerular basement membrane antibodies

General information

Diagnostic test for Goodpasture's syndrome (anti GBM disease)

Specimen transport: At room temperature

Repeat frequency: At significant change of clinical symptoms and post treatment monitoring

Special precautions: Please notify the laboratory if you require an anti GBM antibody result urgently (phone: 0161 276 6440).

Laboratory information

Normal reference range: <0.9 AI

Volume and sample type: 7ml clotted blood

Method: Multiplex Flow Immunoassay

Turnaround time (calendar days from sample receipt to authorised result): Median - 1, 95th percentile - 4

Clinical information

Indications for the test: Rapidly progressive glomerulonephritis.

Factors affecting the test: In comparison to biopsy proven cases of GBM disease, ELISA tests for anti-GBM antibodies have been shown to have a clinical diagnosis agreement of 97%, a sensitivity of 87% and a specificity of 98%. A small number of patients with other renal diseases - systemic vasculitis, SLE and mixed connective tissue disease may exhibit borderline titres.


Clinical workstation reference: GBM


(Last updated October 7th 2014)