IgG subclasses

General information

IgG1, IgG2, IgG3, IgG4

Specimen transport: At room temperature

Repeat frequency: Not within 6 months

Special precautions: None

Laboratory information

Normal reference range: Age and gender specific

Age	IgG1 g/l	IgG2 g/L	IgG3 g/L	IgG4 g/L
0-2 years	1.94-8.42	0.22-3.0	0.186-0.853	0.005-0.784
2-4 years	3.15-9.45	0.36-2.25	0.173-0.673	0.01-0.537
4-6 years	3.06-9.45	0.60-3.45	0.099-1.221	0.018-1.125
6-8 years	2.88-9.18	0.44-3.75	0.155-0.853	0.004-0.992
8-10 years	4.32-10.2	0.72-4.3	0.127-0.853	0.019-0.93
10-12 years	4.23-10.6	0.76-3.55	0.173-1.73	0.016-1.150
12-14 years	3.42-11.5	1.0-4.55	0.283-1.25	0.037-1.360
14-18 years	3.15-8.55	0.64-4.95	2.30-19.6	0.11-1.57
>18 years	3.82-9.28	2.41-7.00	0.21-1.76	0.039-0.864

 

Volume and sample type: 7ml clotted blood

Method: Nephelometry

Turnaround time (calendar days from sample receipt to authorised result):

IgG 1, 3 and 4: Median - 2. IgG 2: Median - 3.

Clinical information

Indications for the test: History of bacterial sinopulmonary infection and IgG between 5-16g/L. History of/or failure to respond to polysaccharide vaccines, pancreatitis (history of recurrent infections - not viral), or abscesses or (failure to respond to immunisation) AND (Total IgG < 0.1 g/l).

Samples not meeting these requirements will be rejected.

Factors affecting the test: None

 

ICE reference: IGG2 Subclass or IGG4 Subclass

 

(Last updated August 22nd 2018)