IgG subclasses

General information

IgG1, IgG2, IgG3, IgG4

Specimen transport: At room temperature

Repeat frequency: Not within 6 months

Special precautions: None

Laboratory information

Normal reference range: Age and gender specific

Age	IgG1 g/l	IgG2 g/L	IgG3 g/L	IgG4 g/L
0-1 days	2.9 - 12.6	1.1 - 6.6	0.2 - 1.4	0.05 - 1.4
1-2 days	2.7 - 14.6	1.1 - 6.9	0.2 - 1.2	0.04 - 1.3
3-6 days	2.4 - 11.6	<1 - 6.4	0.2 - 1.0	0.04 - 1.2
1-2 weeks	2.1 - 10.8	0.7 - 4.9	0.1 - 0.8	0.03 - 0.9
2-4 weeks	1.9 - 9.8	0.5 - 2.9	0.1 - 0.8	0.02 - 0.7
4-8 weeks	1.4 - 8.8	0.3 - 2.6	0.1 - 0.8	0.02 - 0.5
8-16 weeks	1.2 - 8.8	0.3 - 2.6	0.1 - <1	0.02 - 0.3
16-26 weeks	1.6 - 9.8	0.4 - 2.3	0.1 - <1	0.03 - 0.7
6-12 months	1.8 - 10.8	0.5 - 2.3	0.1 - 1.2	0.02 - 1.4
1-4 years	2.4 - 12.6	0.6 - 2.6	0.2 - 1.4	0.02 - 1.8
4-8 years	3.4 - 14.6	0.6 - 2.9	0.2 - 1.3	0.02 - 1.8
8-12 years	3.4 - 11.6	0.7 - 4.4	0.2 - 2.9	0.02 - 1.8
12-16 years	3.4 - 11.6	0.8 - 7.8	0.2 - 2.8	0.03 - 3
16-20 years	3.4 - 11.6	1.1 - 6.6	Male: 0.2-2.0 Female 0.2-1.3	0.05 - 2
20-40 years	2.9 - 12.6	1.1 - 6.6	0.2 - 1.3	0.05 - 2
40-50 years	2.9 - 12.6	1.1 - 6.6	0.2 - 1.3	0.05 - 2
50-70 years	2.9 - 12.6	1.1 - 6.6	0.2 - 1.3	0.05 - 2
70-90+ years	3.9 - 13.6	1.1 - 6.6	0.2 - 1.3	0.05 - 2

 

Volume and sample type: 7ml clotted blood

Method: Nephelometry

Turnaround time (calendar days from sample receipt to authorised result): Median - 1,. 95th percentile - 5

Clinical information

Indications for the test: History of bacterial sinopulmonary infection and IgG between 5-16g/L. History of/or failure to respond to polysaccharide vaccines, pancreatitis (history of recurrent infections - not viral), or abscesses or (failure to respond to immunisation) AND (Total IgG < 0.1 g/l).

Samples not meeting these requirements will be rejected.

Factors affecting the test: None

 

Clinical workstation reference: IgG2 SUBLASS or IgG4 SUBCLASS

 

(Last updated October 7th 2014)