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Immunoglobulins (IgG, IgA, IgM)

General information

IgG: Marked polyclonal IgG elevation is seen in HIV, Sjögren's, and Sarcoidosis. Less marked elevation in chronic inflammatory and infective conditions.
IgA: raised in elderly, chronic infection, cirrhotic liver disease
IgM: raised primary biliary cirrhosis, acute infection, EBV, CMV, TB

Specimen transport: At room temperature

Repeat frequency: Not within six months - exempt for monitoring myeloma and immunodeficiency

Special precautions: None

Laboratory information

Normal reference range: Age specific (5th - 95th centiles)

Age specific reference ranges for total serum IgG, IgA and IgM (as recommended by Pathology Harmony)

Age IgG g/L IgA g/L IgM g/L
Cord 5.2 - 18.0 <0.02 0.02 - 0.2
0-2 weeks 5.0 - 17.0 0.01 - 0.08 0.05 - 0.2
2-6 weeks 3.9 - 13.0 0.02 - 0.15 0.08 - 0.4
6-12 weeks 2.1 - 7.7 0.05 - 0.4 0.15 - 0.7
3-6 months 2.4 - 8.8 0.10 - 0.5 0.2 - 1.0
6-9 months 3.0 - 9.0 0.15 - 0.7 0.4 - 1.6
9-12 months 3.0 - 10.9 0.20 - 0.7 0.6 - 2.1
1-2 years 3.1 - 13.8 0.3 - 1.2 0.5 - 2.2
2-3 years 3.7 - 15.8 0.3 - 1.3 0.5 - 2.2
3-6 years 4.9 - 16.1 0.4 - 2.0 0.5 - 2.0
6-9 years 5.4 - 16.1 0.5 - 2.4 0.5 - 1.8
9-12 years 5.4 - 16.1 0.7 - 2.5 0.5 - 1.8
12-15 years 5.4 - 16.1 0.8 - 2.8 0.5 - 1.9
15-45 years 6.0 - 16.0 0.8 - 2.8 0.5 - 1.9
Over 45 6.0 - 16.0 0.8 - 4.0 0.5 - 2.0

 

Volume and sample type: 7ml clotted blood

Method: Nephelometry

Turnaround time (calendar days from sample receipt to authorised result): Median - 2, 95th percentile - 5

Clinical information

Indications for the test:

  • Recurrent infections
  • Suspected myeloma, Waldenstrom's macroglobulinaemia, lymphoma, connective tissue disease.

Factors affecting the test: Age, primary/secondary immunodeficiency, acute infections, treatment with immunosuppressive drugs, intravenous or subcutaneous immunoglobulin preparations.

 

Clinical workstation reference: IGS and EP

 

(Last updated May 19th 2016)