Platelet Glycoprotein Expression

General information

Platelet glycoprotein expression is useful in the diagnosis of Glanzmann's thrombasthenia and Bernard-Soulier syndrome. These hereditary platelet disorders are characterised by selective deficiencies of platelet membrane glycoproteins.

Specimen transport: At room temperature

Repeat frequency: At significant change of clinical symptoms

Special precautions: The assay should be carried out on blood that is < 24 hours old. Samples can be stored at 4°C prior to analysis. Blood should be taken in to sodium citrate anticoagulant.

Laboratory information

Normal range: >90% positive platelets

Volume and sample type: 5ml citrate blood

Method: Flow cytometric analysis of CD41, CD42b & CD61

Turnaround time (calendar days from sample receipt to authorised result): Median - 1, 95th percentile - 5

Clinical information

Indications for the test: Prolonged bleeding in infancy, haemorrhage, family history

Factors affecting the test: None

 

(Last updated October 7th 2014)