Platelet Glycoprotein Expression
General information
Platelet glycoprotein expression is useful in the diagnosis of
Glanzmann's thrombasthenia and Bernard-Soulier syndrome. These
hereditary platelet disorders are characterised by selective
deficiencies of platelet membrane glycoproteins.
Specimen transport: At room temperature
Repeat frequency: At significant change of
clinical symptoms
Special precautions: The assay should be
carried out on blood that is < 24 hours old. Samples can be
stored at 4°C prior to analysis. Blood should be taken in to sodium
citrate anticoagulant.
Laboratory information
Normal range: >90% positive platelets
Volume and sample type: 5ml citrate blood
Method: Flow cytometric analysis of CD41, CD42b
& CD61
Turnaround time (calendar days from sample
receipt to authorised result): Median - 1, 95th percentile - 5
Clinical information
Indications for the test: Prolonged bleeding in
infancy, haemorrhage, family history
Factors affecting the test: None
(Last updated October 7th
2014)
