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Smooth muscle/mitochondrial antibodies (including liver kidney microsomal (LKM), gastric parietal cell (GPC), and ribosomal)

General information

Smooth muscle antibodies at a high titre are associated with chronic active hepatitis, and at low titres are more likely to be triggered by infection. Mitochondrial antibodies are associated with primary biliary cirrhosis.

Specimen transport: At room temperature

Repeat frequency: At significant change of clinical symptoms

Special precautions: None

Laboratory information

Normal reference range: Neg

Volume and sample type: 7ml clotted blood

Method: Immunofluorescence

Turnaround time (calendar days from sample receipt to authorised result): Median - 3

Clinical information

Indications for the test:

  • Gastric parietal cells: Pernicious anaemia (PA), atrophic gastritis. Present in the early stages of PA, frequently diminish with disease progression.
  • Ab to ribosomes (rRNP): Are associated with psychiatric symptoms of SLE (5-12% of patients) and may be found in RA.

Factors affecting the test: Unable to determine gastric parietal cell antibodies in the presence of mitochondrial antibodies.


ICE reference: Smooth Muscle MITO/LKM/GPC


(Last updated August 22nd 2018)