Smooth muscle/mitochondrial antibodies (including liver kidney microsomal (LKM), gastric parietal cell (GPC), and ribosomal)
Smooth muscle antibodies at a high titre are associated with
chronic active hepatitis, and at low titres are more likely to be
triggered by infection. Mitochondrial antibodies are associated
with primary biliary cirrhosis.
Specimen transport: At room temperature
Repeat frequency: At significant change of
Special precautions: None
Normal reference range: Neg
Volume and sample type: 7ml clotted blood
Turnaround time (calendar days from sample
receipt to authorised result): Median - 3, 95th percentile - 7
Indications for the test:
- Gastric parietal cells: Pernicious anaemia (PA), atrophic
gastritis. Present in the early stages of PA, frequently diminish
with disease progression.
- Ab to ribosomes (rRNP): Are associated with psychiatric
symptoms of SLE (5-12% of patients) and may be found in RA.
Factors affecting the test: Unable to determine
gastric parietal cell antibodies in the presence of mitochondrial
Clinical workstation reference:
(Last updated October 7th