We use cookies to help us improve the website and your experience using it. You may delete and block all cookies from this site at any time. However, please note this may result in parts of the site no longer working correctly. If you continue without changing your settings we will assume you are happy to receive all cookies on this site.


Secondary immunodeficiency

This section deals with secondary immunodeficiency, listing the relevant immunological tests, together with a short explanation of their use.

Relevant immunological tests:

Secondary causes of immunodeficiency are more common than primary causes and levels of immunoglobulins might reflect decreased production (eg. lymphoproliferative disorders, drugs) or increased losses (nephritic syndrome).

In HIV infection the CD4 count is used to monitor progress of disease and inform treatment decisions. Other acute and chronic diseases affect CD4 counts.

In HIV infection they are best done at the same time of day each time and avoiding acute ill health. They should never be done as a substitute to HIV antibody testing to diagnose HIV infection.

Guidelines and information on CD4 counts are available from Aidsmap.

Patient information

Additional patient information is available from:


(Last updated October 8th 2014)