Antibodies associated with neurological conditions
This section deals with the antibodies associated with
neurological conditions, listing the relevant immunological tests,
together with a short explanation of their use.
Relevant immunological tests:
MAG antibodies are detected in 50-75% or patients with IgM
paraproteinaemia and peripheral neuropathy.
Paraneoplastic neuronal antibodies are detected in a number of
neurological conditions where an underlying tumour may be
Anti-Yo antibodies have been found in paraneoplastic cerebellar
Anti-Hu antibodies have been found in paraneoplastic
encephalomyelitis and in sensory neuropathy.
Anti-Ri antibodies can be observed in patients with rapidly
progressive brainstem tumour.
Anti-CV2 antibodies are also found in cerebellar syndromes
usually alongside Hu, Yo or Ri.
Anti-Amphiphysin antibodies can be found in stiff person
Anti Ma1 and Ma2 antibodies can be found in limbic encephalitis,
brainstem encephalitis and cerebellar ataxia.
A negative test result does not exclude the
possibility of a paraneoplastic syndrome.
(Last updated October 10th 2014)