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Antibodies associated with neurological conditions

This section deals with the antibodies associated with neurological conditions, listing the relevant immunological tests, together with a short explanation of their use.

Relevant immunological tests:

MAG antibodies are detected in 50-75% or patients with IgM paraproteinaemia and peripheral neuropathy.

Paraneoplastic neuronal antibodies are detected in a number of neurological conditions where an underlying tumour may be present.

Anti-Yo antibodies have been found in paraneoplastic cerebellar degeneration

Anti-Hu antibodies have been found in paraneoplastic encephalomyelitis and in sensory neuropathy.

Anti-Ri antibodies can be observed in patients with rapidly progressive brainstem tumour.

Anti-CV2 antibodies are also found in cerebellar syndromes usually alongside Hu, Yo or Ri.

Anti-Amphiphysin antibodies can be found in stiff person syndrome.

Anti Ma1 and Ma2 antibodies can be found in limbic encephalitis, brainstem encephalitis and cerebellar ataxia.

A negative test result does not exclude the possibility of a paraneoplastic syndrome.

 

(Last updated October 10th 2014)