This section deals with the clinical condition mysthenia,
listing the relevant immunological tests, together with a short
explanation of their use.
Relevant immunological tests:
Impaired neurotransmission in MG is caused by the presence of
antibodies to acetylcholine receptor. Associated autoantibodies to
skeletal muscle and thyroid microsomes are sometimes also
Although antibodies to acetylcholine receptor (AChR) are present
in all patients with Myasthenia Gravis, they are detectable in only
90% of sera tested in the laboratory.
They are particularly difficult to detect in patients with
ocular myasthenia, where up to 40% of patients have undetected
Antibodies to striated muscle are present in 30% of patients
with MG - and 60% of these will also have a thymoma. This test is
insufficiently reliable to help in management and is no longer
(Last updated October 9th 2014)