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Antiphospholipid antibody syndrome

This section deals with the clinical condition antiphospholipid antibody syndrome, listing the relevant immunological tests, together with a short explanation of their use.

Relevant immunological tests:

Recurrent arterial or venous thrombosis (or foetal loss) may be associated with antibodies to phospholipids including cardiolipin. Related antiphospholipid antibodies include the lupus anticoagulant.

Cardiolipin antibodies may be found in other autoimmune disorders, particularly SLE and are also seen very frequently in acute and chronic infections.

Guidelines suggest that two positive tests (anticardiolipin antibodies, "lupus anticoagulant" - haematology) more than six weeks apart are required to diagnose antiphospholipid syndrome.

More information is available from the BCSH (British Committee for Standards in Haematology) guidelines.


(Last updated October 9th 2014)