Immunology laboratory provides mast cell tryptase testing to meet NICE guidelines on anaphylaxis
NICE clinical guidelines advise on the assessment and referral
of patients presenting with suspected anaphylaxis.
The immunology department is leading on the development of a
local pathway for CMFT that will include referral to the allergy
Investigations to confirm anaphylaxis include timed samples
taken for mast cell tryptase. These should be as soon as possible
without delaying emergency treatment, one to two hours after the
onset of symptoms and at least 24 hours later (convalescence).
The immunology laboratory is able to process the mast cell
tryptase samples and can provide results within one working
The samples need to be clearly marked with the time of sampling
to enable accurate interpretation. These results will help in
clarifying the diagnosis for the patient in the allergy clinic.