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Carbapenemase-Producing Enterobacteriaceae (CPE) Screen (Bacteriology, Wythenshawe campus)

In response to the increasing numbers of CPE producing clinical isolates of Enterobacteriaceaethe Infection Control Consultant and Microbiology department have produced a protocol for CPE screening and detection.

The isolation of a clinical CPE isolate prompts the Infection Control Team to screen all possible patient contacts to reduce the transmission of resistance enzymes within the Trust.

General information

Collection container (including preservatives): Charcoal Swab (please note these are not suitable for the CPE screening method at the Oxford Rd Campus)

CPE

Specimen type: screening of faeces/rectal swabs

Specimen transport: If processing is delayed, refrigeration is preferable to storage at ambient temperature. Delays of over 48hr are undesirable.

Special precautions: None

Laboratory information

Measurement units: MIC mg/L

Turnaround time: Negative screen - 1 working day, positive results - 2-3 working days

Clinical information

Factors known to significantly affect the results: The Modified Hodge Test (MHT) may produce false positive results within isolates that are high level ESBL producers. Occaccisonally isolates can excrete a substance that inhibits the growth of E.coli (such isolates will be referred for PCR confirmation as the MHT is invalid)

 

(Last reviewed March 21st 2018)