India and Pakistan set to benefit from new autism treatment
In a world first, clinical researchers from Universities of
Manchester and Liverpool have collaborated with colleagues in South
Asia to adapt a parent-led autism therapy and successfully test it
in India and Pakistan, with the aim of improving treatment for an
estimated 5 million children in the region with the disorder.
Autism is one of the world's fastest growing developmental
health challenges with up to 70 million people affected, causing a
severe effect on the social development of children. In
developed countries children are able to receive specialist
treatment to improve their interaction with their families, but in
many lower income countries, this is not available.
As a result, researchers, funded by the Autism Speaks Global
Autism Public Health Initiative, adapted a leading UK therapy
method known as PACT, a intervention originating in Manchester,
which help parents interact better with their autistic child.
The resulting PASS (parent-mediated intervention for autism
spectrum disorder in south Asia) programme was taught to
non-specialist health workers in Rawalpindi, Pakistan and Goa,
India who then worked with parents of the 65 autistic children who
were recruited to the trial.
Professor Jonathan Green from University of Manchester and
Professor Atif Rahman from University of Liverpool, lead authors of
the study, said: "We've shown that these techniques can help
children in the UK, but in South Asia, there are factors such as
lack of resources, trained staff, language and cultural differences
and poor access to medical centres which means that methods need to
be adapted. This study is the first to have adapted a treatment so
as to allow it to be delivered by non-specialist health workers in
south Asian communities. It has been outstandingly successful in
showing that such adaptation is both possible and can produce
changes that are equal or even better that we achieved in UK. "
The PASS materials were all presented in the parents' first
language and each period of treatment began with a session on the
causes and misconceptions about the condition.
At the end of the 12 week period the children were assessed
using recognised methods. The parents were shown to have learned
from the intervention and the children more likely to initiate
communication with their parents.
"This pioneering study shows us that it is possible to implement
high quality evidence-based intervention in low resource
communities, even when there are few or no specialists," says Andy
Shih, Autism Speaks vice president of scientific affairs. "It
challenges our notions of best practices and how to deliver
effective services to communities that need them the most."
Dr. Shih leads Autism Speaks' GAPH initiative, which
partners with communities in more than 70 countries worldwide
to increase awareness and access to autism services.
The study did show a decrease in one measure of attention,
suggesting that there are more refinements that need to be made to
PASS, but the Manchester researchers are optimistic that it
represents a cost-effective way of delivering treatment to children
in areas where resources and specialist staff are unlikely to be
Professor Vikram Patel from the London School of Hygene and
Tropical Medicine, one of the senior investigators added: "The key
to developing mental health services in lower income settings is to
develop simple and easily understood treatments that can be carried
out even when specialist staff aren't available.
"This study shows that, for autism, these treatments can make a
significant difference for the social development of children who
would otherwise likely receive little or no help."
The paper, 'Effectiveness of the parent-mediated
intervention for children with autism spectrum disorder in south
Asia in India and Pakistan (PASS): a randomised controlled
trial', was published in the Lancet Psychiatry.
Researchers who also collaborated in this paper also came from,
Institute of Psychiatry, Rawalpindi Medical College, Pakistan; the
Human Development Research Foundation, Islamabad, Pakistan;
Sangath, Goa, India; London School of Hygiene & Tropical
Medicine; University of Liverpool and Royal Manchester Children's
More on PASS and the wider Manchester autism programme can be
More on GAPH and Autism Speaks: