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Grand Rounds and Research and Innovation Exhibition round off a busy year for the Division

December proved to be an eventful month for the Research and Innovation Division as they finished 2009 with the Research and Innovation Exhibition and another stimulating Grand Rounds lecture, this time on personalising cancer treatment. The R&I Exhibition, held on 1st December, was hailed a great success once again, with a poster exhibition and lectures from Andrew Hattersley, Professor of Molecular Medicine, Peninsula Medical School, along with the Trust’s own Professors Graeme Black and Colin Sibley. Prizes on the day included: ‘Informed and uninformed decision making’ - a meta-synthesis of women’s reasoning, experiences and perceptions with regard to advanced maternal age and delayed childbearing Alison Cooke (Research Midwife), Dr Tracey A Mills, Prof Tina Lavender Raised maternal body mass index (BMI) is associated with altered activity of placental nutrient transporters Authors Andrea Ditchfield, Susan Greenwood, Tracey Mills, Mark Wareing & Colin Sibley GLP-1 CellBeads enhance myocardial angiogenesis and improve LV function Kelly Farrell1, Mark Hawthorne1, Christine Wallrapp2, Peter Geigle2, Andrew L. Lewis3, Peter W. Stratford3, Nadim Malik1 Cathy M Holt1 Advanced Glycation End Products (AGEs) Disrupt Cardiac Calcium Handling Through Oxidative Stress Induction Z. Hegab1, S.Gibbons1, T. Mohamed1, C. Schelcher1, M. Shaheen1, D. Oceandy1, L, Neyses, M.A.Mamas1, 2. Sudden cardiac death and genome wide association studies implicate integrin ?7 in cardiac arrhythmias R. Nadif, C. Schelcher, T.M.A. Mohamed, D. Oceandy, U. Mayer*, L. Neyses and E.J. Cartwright Sublingual and Intestinal Microcirculation in patients undergoing Vascular Surgery (SIMVaS) study S Paravastu, P Pemberton, D DeBacker, F Serracino-Inglott, JV Smyth, A Pichel, J Eddleston, MG Walker, M Nirmalan Development of lentiviral mediated stem cell gene therapy for Mucopolysaccharydosis Type IIIA (MPS IIIA) Sergijenko A., Smith A., Langford K., Wilkinson F., Wynn R., Wraith E., Bigger B. Genetic loss of the plasma membrane calcium ATPase 1 (PMCA1) leads to dilated cardiomyopathy and heart failure M.A. Shaheen, M. Zi, S. Prehar, Z. Hegab, T.M.A. Mohamed, F. Baudoin, L. Neyses, E.J. Cartwright. The latest of the Grand Rounds lectures then took place on 9th December in the Postgraduate Centre Lecture Theatre, the keynote speaker being Bill Newman, a lecturer in Genetic Medicine at St Mary’s Hospital. He introduced the lecture with a strand detailing how cancer treatment is selected and the concept of personalised prescription, before handing over to his colleague Roberta Martinez from Genetic Medicine, who went into greater depth about genotyping and various studies currently being undertaken by the Trust. Dr Newman concluded the lecture with a look to the future, and the tailoring of cancer trials to fit each patient’s “molecular profile”, before taking questions from the audience. For further details about upcoming Grand Rounds, please email caroline.boston@cmft.nhs.uk.