Dr Fiona Dignan
BSc Med Sci (hons) MBChB FRCP FRCPath MD (Res)
Stem cell transplantation, Graft-versus-host disease, Chronic Myeloid leukaemia
Dr Fiona Dignan is a consultant in haemato-oncology and has been clinical lead for haematology since 2015. Her main clinical interests are acute leukaemia, chronic myeloid leukaemia and allogeneic transplantation. She undertook her haematology training at The Royal Marsden in London and developed a research interest in post-transplant complications including infection and graft-versus-host disease. She undertook an MD research degree from University College London on novel strategies for managing graft-versus-host disease which has led to a number of national and international presentations and peer-reviewed journal articles.
She is the lead author of national clinical practice guidelines on graft-versus-host disease, respiratory viral infections and veno-occlusive disease following haematopoietic stem cell transplantation. She is treasurer of the British Society for Blood and Marrow Transplantation and has been a member of the working party for the National Institutes of Health consensus project on chronic graft-versus-host disease. She is also a member of the British and American Societies for Haematology and a fellow of the Royal College of Physicians Edinburgh. She represents the north of England on the clinical reference group for bone marrow transplantation.
0161 276 3361
Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf
M, Arat M, Bader P, Baron F, Bazarbachi A, Blaise D, Ciceri F,
Corbacioglu S, Dalle JH, Dignan
F, Fukuda T, Huynh A, Masszi T, Michallet M,
Nagler A, NiChonghaile M, Okamoto S, Pagliuca A, Peters C, Petersen
FB, Richardson PG, Ruutu T, Savani BN, Wallhult E, Yakoub-Agha I,
Duarte RF, Carreras E. Revised
diagnosis and severity criteria for sinusoidal obstruction
syndrome/veno-occlusive disease in adult patients: a new
classification from the European Society for Blood and Marrow
Bone Marrow Transplant. 2016
Lee SJ, Wolff D, Kitko C, Koreth J, Inamoto Y, Jagasia M,
Pidala J, Olivieri A, Martin PJ, Przepiorka D, Pusic I,
Dignan F, Mitchell SA, Lawitschka
A, Jacobsohn D, Hall AM, Flowers ME, Schultz KR, Vogelsang G,
Pavletic S. Measuring
Therapeutic Response in Chronic Graft-versus-Host Disease. National
Institutes of Health Consensus Development Project on Criteria for
Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2014
Response Criteria Working Group Report
Biol Blood Marrow Transplant. 2015
Taylor PC, Dignan F,
El-Ghariani K, Griffin J, Gennery AR, Bonney D, Das-Gupta E, Lawson
S, Malladi RK, Douglas KW, Maher T, Guest J, Hartlett L, Fisher AJ,
Child F, Scarisbrick JJ. The
role of extracorporeal photopheresis in the management of cutaneous
T-cell lymphoma, graft-versus-host disease and organ transplant
rejection: a consensus statement update from the UK Photopheresis
Society. Br J Haematol. 2017
Feb 21. doi: 10.1111/bjh.14537. [Epub ahead of print]
Dignan FL, Clark A, Aitken C,
Gilleece M, Jayakar V, Krishnamurthy P, Pagliuca A, Potter MN, Shaw
B, Skinner R, Turner A, Wynn RF, Coyle P; Haemato-oncology Task
Force of the British Committee for Standards in Haematology;
British Society for Blood and Marrow Transplantation and the UK
Clinical Virology Network. BCSH/BSBMT/UK
clinical virology network guideline: diagnosis and management of
common respiratory viral infections in patients undergoing
treatment for haematological malignancies or stem cell
transplantation. Br J
FL, Wynn RF, Hadzic N, Karani J, Quaglia A,
Pagliuca A, Veys P, Potter MN; on behalf of the
Haemato-oncology Task Force of the British Committee for Standards
in Haematology and the British Society for Blood and Marrow
Transplantation. Diagnosis and Management of
Veno-occlusive Disease (Sinusoidal Obstruction Syndrome) following
Haematopoietic Stem Cell Transplantation.
Br J Haematol. 2013 Sep
17. doi: 10.1111/bjh.12558. [Epub ahead
Dignan FL, Clark A, Amrolia P,
Cornish J, Jackson G, Mahendra P, Scarisbrick JJ, Taylor PC, Hadzic
N, Shaw BE, Potter MN; on behalf of the Haemato-oncology Task Force
of the British Committee for Standards in Haematology and the
British Society for Blood and Marrow Transplantation. Diagnosis and
management of acute graft-versus-host disease.
Br J Haematol.
FL, Amrolia P, Clark A, Cornish J, Jackson G,
Mahendra P, Scarisbrick JJ, Taylor PC, Shaw BE, Potter MN; on
behalf of the Haemato-oncology Task Force of the British Committee
for Standards in Haematology and the British Society for Blood and
Marrow Transplantation. Diagnosis and
management of chronic graft-versus-host disease.
Br J Haematol.
Dignan FL, Scarisbrick JJ, Cornish
J, Clark A, Amrolia P, Jackson G, Mahendra P, Taylor PC, Shah P,
Lightman S, Fortune F, Kibbler C, Andreyev J, Albanese A, Hadzic N,
Potter MN, Shaw BE; on behalf of the Haemato-oncology Task Force of
the British Committee for Standards in Haematology and the British
Society for Blood and Marrow Transplantation. Organ-specific
management and supportive care in chronic graft-versus-host
disease. Br J
Gorcea CM, Tholouli E, Turner A, Saif M, Davies
E, Battersby E, Dignan
Effective use of oral ribavirin for respiratory syncytial
viral infections in allogeneic haematopoietic stem cell transplant
recipients. Journal of
Hospital Infection. 2017
Routledge DJ, Tower C, Davies E, Scott M, Waller
M, Burthem J, Dignan
Successful management of acute myeloid leukaemia in a twin
pregnancy - a case report.
British Journal of Haematology 2016 Oct
21. doi: 10.1111/bjh.14418.
Scarisbrick JJ, Dignan FL,
Tulpule S, Gupta ED, Kolade S, Shaw B, Evison F, Shah G,
Tholouli E, Mufti G, Pagliuca A, Malladi R, Raj K. A multicentre UK
study of GVHD following DLI: Rates of GVHD are high but mortality
from GVHD is infrequent.
Bone Marrow Transplant. 2015 vol. 50
(1) pp 62-67
Nikolousis E, Nagra S, Pearce R, Perry J, Kirkland K, Byrne
J, Dignan F, Tholouli E,
Gilleece M, Russell N, Littlewood T, Cook M, Peniket A, Shaw BE,
Cook G, Craddock C.
pre-transplant co-morbidities on outcome after alemtuzumab-based
reduced intensity conditioning allo-SCT in elderly patients: A
British Society of Blood and Marrow Transplantation
study. Bone Marrow
Transplant. 2015 vol. 50 (1) pp 82-6
Das-Gupta E, Dignan F,
Shaw B, Raj K, Malladi R, Gennery A, Bonney D, Taylor P,
Scarisbrick J. Extracorporeal
photopheresis for treatment of adults and children with acute GVHD:
UK consensus statement and review of published
literature. Bone Marrow
Transplant. 2014 Oct;49(10):1251-8.
FL, Aguilar S, ScarisbrickJJ, Shaw
BE, PotterMN, Cavenagh J, Apperley JF, Fielding AF,
Pagliuca A, Raj K, Marks D, Peniket A, Crawley C, Koh MB, Child FJ
Impact of Extracorporeal Photopheresis on Skin scores and Quality
of Life in Patients with Steroid-refractory Chronic
Graft-versus-Host Disease Bone Marrow
Transplant, 2014 May;49(5):704-8
Anthias C, Dignan
FL, Morilla R, Morilla A, Ethell
ME, Potter MN, Shaw BE.
MRD predicts outcome following reduced-intensity and myeloablative
allogeneic hemopoietic SCT in
2014 Feb 10.
Potter MN, Ethell ME, Taylor M, Lewis L, Brennan J, McNamara L,
Evans SO, Riley U, Davies FE, Dearden CE, Morgan GJ, Shaw BE. High readmission
rates are associated with a significant economic burden and poor
outcome in patients with grade III/IV acute GvHD.
Clin Transplant. 2013
Greenblatt D, Cox M, Cavenagh J, Oakervee H, Apperley JF, Fielding
AK, Pagliuca A, Mufti G, Raj K, Marks DI, Amrolia P, Peniket A,
Medd P, Potter MN, Shaw BE, Scarisbrick JJ. Efficacy of
bimonthly extracorporeal photopheresis in refractory chronic
mucocutaneous GVHD. Bone Marrow
F, Evans S, Ethell M, Shaw B, Dearden C, Davies
F, Treleaven J, Riley U, Morgan G, Potter M.An early
CT-diagnosis based treatment strategy for invasive fungal infection
in allogeneic transplant recipients using caspofungin first line:
an effective strategy with low mortality.Bone
Marrow Transplant 2009
F, Gujral D, Ethell M, Evans S, Treleaven J,
Morgan G, Potter M. Prophylactic defibrotide in allogeneic stem
cell transplantation: minimal morbidity and zero mortality from
veno-occlusive disease. Bone Marrow
Transplant 2007 Jul; 40(1): 79-82.
F, Alvares C, Riley U, Ethell M, Cunningham D,
Treleaven J, Ashley S, Bendig J, Morgan G, Potter M. Parainfluenza
type 3 infection post stem cell transplant: high prevalence but low
mortality. J Hosp Infect 2006
Aug; 63(4): 452-8.
Burke JP, Hay
I, Dignan F, Goellner JR,
Achenbach SJ, Oberg AL, Melton LJ. Long-Term Trends in Thyroid
Carcinoma: A Population-Based Study in Olmsted County, Minnesota,
1935-1999.Mayo Clinic Proceedings
2005 Jun; 80(6): 753-8.
RT, Dignan FL, Lee H, Seiden
MV, Gallagher CJ, Matulonis UA, Olson K, Gibbens I and Gore ME.
Attitudes to Chemotherapy in Patients with Ovarian
Cancer.Gynecologic Oncology 2004
FL, Abu-Arafeh I, Russell G. The Prognosis of
Abdominal Migraine. Arch Dis Child
2001; 84: 415-418.
FL, Symon D, Abu-Arafeh I, Russell G. The
Prognosis of the Cyclical Vomiting Syndrome. Arch
Dis Child 2001; 84: 55-57.
Scarisbrick J. Extracorporeal Photopheresis. In: Hamblin MR, Huang
Y (eds) Harvard Medical School, Boston Handbook of
Photomedicine Taylor & Francis
F, Potter M. Haematopoetic Stem Cell
Transplantation: An update. MIMS Oncology and
Palliative Care Journal, 2010.
RT, Dignan FL, Canellos GP,
Picard CL, Lynch TJ. Burnout: Caring for the Caregivers.
The Oncologist 2000; 5: 425-434. (Based
on Schwartz centre round at Massachusetts General
Manwani R, Potter MN, Ethell ME, Leonard H, Brennan J, Baker J,
Shaw BE. A
dedicated GvHD clinic may improve the quality of life for
allogeneic stem cell transplant survivors.
Shaw BE. An early
computed tomography-guided antifungal treatment strategy is safe
and efficacious in patients undergoing chemotherapy for high-risk
acute leukemia. Leuk
Dignan F, Taylor S, Potter M,
Cubitt D, Treleaven JG. Another case of PORN (bilateral progressive
outer retinal necrosis) after allogeneic stem cell
transplantation. Bone Marrow
Transplant 2006 Jan; 37(1): 113-4.
Russell G, Abu-Arafeh I, Dignan
F. Abdominal Migraine.
Cephalagia 2003 Apr; 23 (3): 242;
author reply 242.