New drug trial offers hope to women who miscarry
Doctors at Saint Mary's Hospital are inviting women who have
had three or more unexplained miscarriages to take part in a trial
of a new drug treatment which may help to reduce the risk of
The PROMISE (Progesterone in Recurrent Miscarriage) trial is
using progesterone treatment in women who have had three or more
miscarriages (which do not have to be one after another, some
participants have had one miscarriage, a baby and then two or more
miscarriages), and comparing it with a placebo (dummy drug).
Manchester is one of a network of centres in England, Scotland
and the Netherlands taking part in the study, which is funded by
the National Institute for Health Research (NIHR).
The lead investigator at Saint Mary's is Dr Edmond Edi-Osagie,
supported by research nurse Lucy Dwyer, and recruitment for the
trial has now begun.
"In many cases, there is no clear explanation about why a woman
loses her baby, and it can be very upsetting and worrying for
couples if they experience repeated miscarriages," said Dr
Edi-Osagie. "The purpose of this study is to find out whether
treating these women with progesterone, a natural pregnancy
hormone, from the time of a positive pregnancy test until 12 weeks
of pregnancy decreases their chance of miscarrying."
Women taking part in the Trial administer pessaries twice a day
at home, from the time they have a positive pregnancy test until
they have used up the entire pack, which should take them to
approximately 12 weeks of their pregnancy. . The research
team will follow up each participant regularly during the trial
period and then keep in touch as the pregnancy progresses and after
their babies are born.
Dr Edi-Osagie added: "We do not
know if the study will help the women who participate personally,
but the information we will get may improve the pregnancy outcome
for women in the future."
The research is sponsored by Imperial College, London (Chief
Investigator - Dr Raj Rai) and managed by the University of
Birmingham (Trial Manager - Prof Arri Coomarasamy). The
Manchester site is also supported by the NIHR Manchester Biomedical
If you would like more information about the trial please
contact Lucy Dwyer at Saint Mary's Hospital at firstname.lastname@example.org or
on 07779 160534 or bleep 2335 via switchboard 0161 276 1234. You do
not need to be referred to the PROMISE trial by your GP but you may
require additional tests to determine whether you are eligible to
participate or not.