The 100,000 Genomes Project
What's it all about?
Ever typed '100,000' into your Google search bar? You may be
surprised to see the 100,000 Genomes Project come first.
The initiative involves collecting and decoding 100,000 human
genomes - complete sets of people's genes - that will enable
scientists and doctors to understand more about specific
Here Professor Sue Hill, NHS Chief Scientific Officer for
England, explains how the project is driving real transformation by
bringing 21st century medicine to the NHS.
Saint Mary's Hospital leads the Greater Manchester Genomic
Medicine Centre, along with partner organisations across the
What is the 100,000 Genomes Project about?
In a nutshell, it's a national project to transform healthcare
for the future that allies cutting edge science and technology,
clinical care and research. By the end of 2017, the project is
aiming to sequence 100,000 whole human genomes (all the information
in our DNA that make us who we are) from around 70,000 people.
What's the vision?
Understanding DNA and how it can predict and prevent disease,
provide a precise diagnosis and direct targeted treatment will soon
play a role in every aspect of medicine, from cancer to cardiology.
We want to become the first country to introduce whole genome
sequencing as a mainstream part of our national healthcare system.
Better understanding genomics will help us transform how we care
for patients, from one-size-fits-all to
How does it work?
The project is focusing on patients with rare diseases and their
close relatives and patients with cancer. It's a collaborative
project: NHS England is developing the delivery infrastructure
in the health service via NHS Genomic Medicine
Centres. Genomics England is co-ordinating the sequencing
and interpretation capacity and capability and focusing the
parallel research and life science industry endeavours in the UK
and abroad. Health Education England is tasked with the
upskilling of all healthcare professionals. Alongside
this, Public Health England is looking at how genomics
can help in the battle against infectious disease, while
the Department of Health provides stewardship of the
Project and leads on the wider genomics policy.
What are NHS Genomic Medicine Centres?
In 2014, NHS England designated the first 11 NHS Genomic
Medicine Centres (GMCs) across England (with more coming in the New
Year). Each covers a distinct geography of about 3-5 million people
and consists of a lead organisation (a Trust) working as a network
with other partner organisations in their area (local delivery
partners) to a tightly defined service specification to ensure
consistency, quality and comparability.
Where can I find out more?
- Talk to a member of the Manchester GMC team, which is
based at Saint Mary's Hospital in Manchester,
on 0161 276 6506.
- Take a look at the story of Michelle Holding, and her mother Suzanne.
- Listen to some of our patients talking about their experiences here.
Genomics England's website has a host of information for
patients and the public.
- Interested in genomics education and training for NHS staff?
Please visit Health Education
- Keep up to date with genomics in Manchester by following
@CMFT_Genomics and keep up to date with the project by following
@GenomicsEngland and @genomicsedu. Tweet or RT using the
recruits to the project: Michelle Holding and her mother,
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